Protein Labeling Reagents
Biotium Cytokeratin 17(E3), CF488A conjugate, 0.1mg/mL
Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered asepithelial stem cellmarker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype
Biotium CD28(C28/75), CF488A conjugate, 0.1mg/mL
Recognizes a glycoprotein of 44-88 kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium CD28(C28/74), CF488A conjugate, 0.1mg/mL
Recognizes a glycoprotein of 44-88 kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium CD11c(HC1/1), CF488A conjugate, 0.1mg/mL
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells. It induces cellular activation and helps trigger neutrophil respiratory burst. It is expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium CD19(CVID3/155), CF488A conjugate, 0.1mg/mL
Recognizes a protein of 95 kDa, identified as CD19. CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.Primary antibodies are available purified, or w
Biotium CD11c(HC1/1), CF488A conjugate, 0.1mg/mL
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells. It induces cellular activation and helps trigger neutrophil respiratory burst. It is expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Medchemexpress LLC HY-100335 50mg Medchemexpress, PCI-33380 CAS:1022899-36-0 Purity:>98%
Medchemexpress, HY-100335 50mg PCI-33380 CAS:1022899-36-0 PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
(=O)=O)=c5cc4Oc3cc2N1CCCC(=O)Oc1c(F)c(F)cc(F)c1F | 1mg | 713699957](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502459213.PNG-250.jpg)
eMolecules MB 660R TFP Ester | Broadpharm |891.920 | C37H41F4N3O12S3 | 0.000 | CC1(C)CC(CS(O)(=O)=O)c2cc3N=c4cc5C(CS(O)(=O)=O)CC(C)(C)[N+](CCCS([O-])(=O)=O)=c5cc4Oc3cc2N1CCCC(=O)Oc1c(F)c(F)cc(F)c1F | 1mg | 713699957
MB 660R TFP Ester | Broadpharm |891.920 | C37H41F4N3O12S3 | 0.000 | CC1(C)CC(CS(O)(=O)=O)c2cc3N=c4cc5C(CS(O)(=O)=O)CC(C)(C)[N+](CCCS([O-])(=O)=O)=c5cc4Oc3cc2N1CCCC(=O)Oc1c(F)c(F)cc(F)c1F | 1mg | 713699957
![eMolecules 197306-80-2 | BDP TR X NHS ester | Broadpharm634.460 | C31H29BF2N4O6S | 0.000 | F[B-]1(F)n2c(ccc2-c2ccc(OCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)cc2)C=C2C=CC(c3cccs3)=[N+]12 | 1mg | 761705583](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502459511.PNG-250.jpg)
eMolecules 197306-80-2 | BDP TR X NHS ester | Broadpharm634.460 | C31H29BF2N4O6S | 0.000 | F[B-]1(F)n2c(ccc2-c2ccc(OCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)cc2)C=C2C=CC(c3cccs3)=[N+]12 | 1mg | 761705583
BDP TR X NHS ester | Broadpharm | 197306-80-2634.460 | C31H29BF2N4O6S | 0.000 | F[B-]1(F)n2c(ccc2-c2ccc(OCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)cc2)C=C2C=CC(c3cccs3)=[N+]12 | 1mg | 761705583
Biotium Human Lambda Light Chain(HP6054), CF568 conjugate, 0.1mg/mL
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can
Biotium Cytokeratin, multi(C11), CF568 conjugate, 0.1mg/mL
This MAb recognizes cytokeratin 4, 5, 6, 8, 10, 13, and 18. This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.